Dr. Juergen Arnhold

Local deep radiofrequency hyperthermia:

The history of hyperthermia reaches back to the times of hippokrates in the ancient greecs medicin over 3500 years ago. With modern computer controlled equipment it is possible to apply a spot heat to tumors and metastases. The temperature can reach 45°C at the focus of the application. Starting at 42°C heat shock proteins appear at the surface of the cancer cells can be identifid and destroyed by the patients immun competent cells like T-cells and naturel killar cells.

Dendritic cell therapy for cancer (immunotherapy):

Dendritic cell therapys for the treatment of cancer deseases have been introduced in the beginning of the `80th first for the treatment for the renal cancer . Now we have an overview over almost thirty years and experience with the mode of action of dendritic cells. Many of scientifics articles have been published and in May 2010 the FDA in the USA released Provenge for the treatment of prostate cancer, because of its good therapeutical effect demonstrated in large clinicle trials. The dendritic cell vaccines are produced from the patients own blood in special laboratories .

After the production is finished, which takes about ten days, the dendritic cell vaccine loaded up with certain antigens is applicated back to the patient as an intradermal, intranodal, intravenous or intratumoral injection. The dendritic cell therapy should be administerd under hyperthermia conditions with simultaneous low dose oral chemotherapy (Cyclophosphamid 50mg/ per day/ p.o about one week before the injection.)

The procedure should be repeated 6 times every 2 to 4 weeks to achieve a high level of immun reaction. This therapy can be used for various cancer deseases like prostate-, breast-, colonic-, kidney-, pankreas- and skin cancer.

Hyperthermie:

Tumorgewebe ist besonders hitzeempfindlich. Bei Temperaturen von 42 Grad kommt es an der Zellmembran zu Schädigungen, es bilden sich auf der Oberfläche der Tumorzelle sogenannte Hitzeschockproteine, dies sind charakteristische Eiweißstrukturen, die die natürlichen Killerzellen des Immunsystems zum Angriff auf die Tumorzellen aktivieren.
Außerdem wird die Wirksamkeit von Zytostatika und Strahlen erhöht. Zur Hyperthermie werden Mikrowellen, Radiowellen, Ultraschallwellen oder Infrarotstrahlen eingesetzt. Die optimale Wirkung auf Tumorzellen wird bei 41,5 bis 42 Grad erreicht. Die Hyperthermie
- ist eine sinnvolle Erweiterung der Krebstherapie
- kann zu langfristigen Remissionen beitragen
- kann Primärtumoren verkleinern und Metastasenrückbildung bewirken

Durch Hyperthermie alleine werden nicht alle Tumorzellen geschädigt. Deshalb kombiniert man sie mit einer Chemo-, Strahlen- und /oder Immuntherapie. Dabei kann die Dosis der Chemo- oder Strahlentherapie deutlich reduziert werden.

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Whole body Hyperthermia treatment:

A. Allgemeines
With this therapy, the patients body is heated up to a fever range, because cancer sells are very sensitive to heat and can be selectively destroyed. The normal tissue is not effected from the heat. Another advantage of the hyperthermia is that the encreasing temperature induces immun reactions in the patient immunsystem to fight cancer cells. Whole body hyperthermia also enhances the effect of chemotherapy even at lower dose levels. The treatment can be done at moderate temperature levels up to 39,5° C (103,1°F) or with dedation extrem level up to 41,5°C(106,7°F)

During the therapy all vital functions are intensive monitored. For standing the treatment which takes about 3 hours the patient should be in an acceptable over all condition. Patients with reduced heart or lung function can not be included.

Urology:
Prostate imaging with:

transrectal ultrasound and elastography
MRI-Spectroscopy
dendritic cell-therapy for prostate cancer and other malignancies
chemotherapy
Brachytherapy (Seeds)